IL10 and Stroke: Since inflammation develops rapidly after an epileptogenic insult, scientific literature has suggested the important role of the brain pro-inflammatory milieu in the development of a maladaptive process that leads to epilepsy 23. Here, we also found that IL-10 is acutely increased after stroke in Proechimys. Interleukin-10 exhibits potent anti-inflammatory properties and worse neurological outcomes are reported in patients with low IL-10 plasma levels during the first hours after stroke 24.