Captivated by this favorable data in single association analysis, further investigation was conducted using combined allele from IVS2-74T>G, IVS2-16G>C, IVS2-666C>T, 3'UTR + 233G>C and 3'UTRt + 314G>A of HBB gene in an attempt to evaluate the predisposing effect of HBB intragenic haplotype with beta-thalassemia. Here, HBB is linked to beta thalassemia.