CD4 and neoplasm: Indeed, although fewer infiltrating CD4+ and CD8+ T cells per tumor area were observed in aggressive lesions relative to indolent lesions (Supplementary Fig. 6a–d), subset analysis of T cell clusters (T cell 1–4) revealed that immune-suppressed T cell populations (identified using exhaustion scores calculated from the expression of genes associated with immune suppression) were increased in relative frequency in aggressive lesions (Supplementary Fig. 6e–h).