Intriguingly, immunohistochemical analysis of tumor sections from CRC patients with obesity highlighted that adipose cells, marked by high expression of adiponectin, were located at tumor invasive front and interspersed among tumor cells expressing CDX2 and covering the 28% of the entire tumor mass (Fig. 1c and Supplementary Fig. 1c, d). Here, CDX2 is linked to obesity due to melanocortin 4 receptor deficiency.