HIF-1α plays a key role in regulating metabolic pathways and inflammatory responses.43 Dysregulation of the HIF-1α pathway promotes multiple diseases including cancer, cardiovascular disease, and Alzheimer’s disease.44–47 Particularly, HIF-1α also contributes to the regulation of the aging process47. The gene discussed is HIF1A; the disease is early-onset autosomal dominant Alzheimer disease.