We propose a similar role for HLTF and SHPRH to Rad5 in rNMP bypass and that mutations in those genes could increase the severity of diseases associated with mutations in RNase H2 such as Aicardi Goutières syndrome and Systemic Lupus Erythematosus (Günther et al, 2015). This evidence concerns the gene HLTF and Aicardi-Goutieres syndrome.