Under the condition of hyperglycemia, advanced glycosylation end products (AGEs) and its main signal receptor RAGE interact with each other, which can lead to the abnormal function of immune cells, change the phenotype and function of other important cells in periodontal tissues, and increase the expression of pro-inflammatory cytokines (Interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α) [7]. The gene discussed is TNF; the disease is Hyperglycemia.