TLR5 and systemic lupus erythematosus: It has been reported that C1174T substitution in TLR5 resulting in a stop codon polymorphism causes significantly lower levels of proinflammatory cytokines in comparison to individuals with the wild-type genotype and that the TLR5 stop codon polymorphism is associated with protection from the development of systemic lupus erythematosus [5].