C2orf80 and breast cancer: In the same subgroup of grade 3 tumors, we observed a noteworthy, non-genome-wide significant association with variant rs66871326, located on chromosome 2 in an intron of C2orf80. For variant rs66871326, the alternative A allele was associated with decreased risk of breast cancer death (HR [95% CI] 0.85 [0.80,0.90], P = 2.1E−07, BFDP = 0.11).