Variant rs56248395, located on chromosome 11 in an intron of NAV2 (Additional file 2: Supplementary Figure S5), was associated with breast cancer death in the subgroup of patients with an ER+ or PR+ and HER2− tumor who did not receive chemotherapy (HR [95% CI] 2.33 [1.72,3.15], P = 4.8E−08, per T allele; Table 1). Here, ESR1 is linked to breast cancer.