Based on a more realistic IC/BPS rat model, this study elucidated the promoting effect of IL‐6 on the inflammatory progression of IC/BPS, and confirmed that IL‐6 is one of the key factors in the role of inflammation, which provided a theoretical and experimental basis for the further study of IL‐6 in the etiological mechanism of IC/BPS. The gene discussed is IL6; the disease is Bartsocas-Papas syndrome 1.