IL6 and Bartsocas-Papas syndrome 1: In this study, we investigated the influence of IL‐6 on the occurrence and progression of IC/BPS in the rat model of IC/BPS, and further explored the cell source of highly expressed IL‐6, and drew the following conclusions: IL‐6 may be a key inflammatory mediator in the occurrence and progression of IC/BPS, and has a direct influence on the development of inflammation in animal models.