Admittedly, there were still some shortcomings in this study: first, this study has proved that IL‐6 has a pro‐inflammatory effect in IC/BPS model rats, and IL‐6R has the effect of reducing inflammation, while without further exploring the upstream pathway regulating the synthesis and secretion of IL‐6 by macrophages. This evidence concerns the gene IL6R and Bartsocas-Papas syndrome 1.