In addition, there were a large number of immune‐related studies on IC/BPS have also found that the inflammatory progression of IC/BPS is related to the expression levels of inflammatory cytokines such as interleukin 6 (IL‐6), IL‐17, and IL‐1β, and is also related to mast cell activation.9, 10, 11. This evidence concerns the gene IL6 and Bartsocas-Papas syndrome 1.