SCF‐independent spontaneous activating c‐Kit mutations are detected in approximately 85%, 30%, 25%, 25%, and 90% of gastrointestinal stromal tumors (GISTs), acute myeloid leukemias, acral melanomas, testicular carcinomas, and systemic mastocytosis (SM) cases, respectively [4]. This evidence concerns the gene KIT and gastrointestinal stromal tumor.