NFKB1 and adult T-cell leukemia/lymphoma: To determine whether CQ-mediated inhibition of ATLL cell growth is associated with suppression of NF-kB through blockade of p47 degradation via autophagic flux, we initially assayed the turnover of LC3-phospholipid conjugate (LC3-II) as an autophagic marker protein in ATLL cell lines (Su9T01, KOB, KK1, and S1T) that were either untreated or treated with various doses of CQ.