PUM3 and esophageal adenocarcinoma: Using the Kaplan Meier Plotter (http://kmplot.com/analysis/index.php?p=service&cancer) [19], a publicly accessible database, a high level of PUF-A mRNA is noticeably associated with poor survival in cervical squamous carcinoma, liver hepatocellular carcinoma, pancreatic ductal adenocarcinoma, esophageal adenocarcinoma and kidney renal clear cell carcinoma (Fig 1A-1E).