Previous clinical studies show that lnc-ITSN1-2 expression is upregulated and its high expression correlates with elevated inflammation (including CRP, TNFα, and IL-17A) and increased disease activity reflected by DAS28 score in patients with RA (Gong et al. 2017; Yue et al. 2019). This evidence concerns the gene IL17A and rheumatoid arthritis.