As a newly identified lncRNA, lncRNA intersectin 1-2 (lnc-ITSN1-2) may induce inflammation in the fibroblast-like synoviocytes (FLS) of rheumatoid arthritis (RA) through promoting the nucleotide-binding oligomerization domain 2 (NOD2)/receptor-interacting protein 2 (RIP2) axis (Yue et al. 2019). This evidence concerns the gene NOD2 and rheumatoid arthritis.