Although POLβ cytoplasmic expression in pure DCIS did not show significant associations with patient outcome, combined analysis of N/C expression revealed that L.N/L.C cluster was associated with shorter LRFI (p = 0.022, HR = 2.234, 95% CI 1.125–4.436) (Fig. 3E). The gene discussed is POLB; the disease is ductal breast carcinoma in situ.