NES and medulloblastoma: The SHH group of medulloblastoma reflects the specific temporal changes in gene expression that typify granule cell precursors, whereas group 3 medulloblastoma resembles VZ and RL stem cells, marked by Nestin expression, and group 4 medulloblastoma cells display a gene expression signature similar to unipolar brush cells [151]. In this scenario, it can be envisioned that application of single-cell technologies to specific cerebellar sub-regions may also help dissecting the gene expression programs that differentiate regional cerebellar circuits.