These combinations are specified in the main PanelPRO function call, where the user should indicate the cancers for which family history in the pedigree should be used, as well as the genes for which carrier probabilities are requested.PanelPRO(pedigree = test_fam_1,                      cancers = c(‘Breast’, ‘Ovarian’),                      genes = c(‘BRCA1’, ‘BRCA2’, ‘ATM’, ‘MSH2’)). Here, ATM is linked to cancer.