In the current PanelPRO database, cancer penetrances are taken from data included in the BayesMendel package when available: the BRCA1 and BRCA2 estimates for the probability of developing breast or ovarian cancer Chen et al., 2020; the MLH1, MSH2, and MSH6 estimates for the probability of developing colorectal or endometrial cancer Wang et al., 2020; Felton et al., 2007; and the CDKN2A estimates for the probability of developing melanoma (Wang et al., 2010; Begg et al., 2005; Bishop, 2002). The gene discussed is MSH6; the disease is cancer.