Enhanced cardiac SERCA2a function due to SIRT3 overexpression is a noteworthy result because alterations to SERCA2a function are often detected in the diseased human heart, and therapies that increase cardiac SERCA2a activity may have potential for the treatment of heart disease (Gwathmey et al., 2011, 2013; Jaski et al., 2009). This evidence concerns the gene SIRT3 and heart disorder.