It is well established that glucagon responses to hypoglycemia are severely impaired in type 1 diabetes (Bengtsen et al., 2020; Cryer et al., 2001; Gerich et al., 1973) but whether glucagon secretion is completely intact following other physiological and metabolic stressful stimuli compared with nondiabetic individuals has been less thoroughly investigated. Here, GCG is linked to type 1 diabetes mellitus.