GCG and Hypoglycemia: The loss of glucagon responses to hypoglycemia seems irreparable in the course of the disease, and despite scrupulously avoidance of hypoglycemia for four months the glucagon response remains absent whereas epinephrine and hypoglycemic symptoms rematerialize (Cranston et al., 1994), supporting the notion that the loss of glucagon responses to hypoglycemia is irreversible.