The counter regulatory metabolic response is highly efficient in people without diabetes, whereas individuals with type 1 diabetes are more susceptible to hypoglycemia due to several factors, including chronic sustained hyperinsulinemia (Gregory et al., 2019), repeated episodes of hypoglycemia impairing the hormonal counter regulatory response and attenuating symptoms to subsequent hypoglycemia (i.e., hypoglycemia‐associated autonomic failure) and due to severely impaired glucagon responses to hypoglycemia as outlined below. The gene discussed is GCG; the disease is Hypoglycemia.