Exogenous T4 improved glucose intolerance in obese, insulin resistant Otsuka Long Evans Tokushima Fatty (OLETF) rats that have otherwise normal functioning thyroid gland (Vazquez‐Anaya et al., 2017) suggesting that chronically (Tyagi et al., 2011) elevated T4 improves glucose intolerance and insulin resistance. This evidence concerns the gene INS and Insulin resistance.