UTX (ubiquitously transcribed tetratricopeptide repeat gene on X chromosome), a histone demethylase usually functions by removing the EZH2’s methylation of the di‐or trimethylated H3K27, and mutations in UTX has been identified in many cancers such as bladder, pancreatic, renal, medulloblastoma and multiple myeloma.41, 42, 43, 44. This evidence concerns the gene EZH2 and plasma cell myeloma.