For example, M1-macrophages are considered to possess anti-tumor functions by phagocytosing and producing Th1‐promoting cytokines, such as IL‐12, IL‐23, and TNF‐α, while M2‐macrophages are thought to have pro-tumor functions by regulating angiogenesis, suppressing immune surveillance, promoting inflammation, and stimulating cancer cell motility by secreting growth factors and chemokines (IL‐10, TGF‐β, PD‐L1, and ARG‐1) (Engblom et al., 2016). Here, ARG1 is linked to neoplasm.