The analysis revealed that CDKN2A was positively correlated with tumor purity (cor = 0.178, P=0.000), B cells (cor = 0.259, P=0.0000), CD8 + T cells (cor = 0.261, P=0.000), neutrophils (cor = 0.257, P=0.000), especially with CD4 + T cells (cor = 0.186, P=0.000), macrophages (cor = 0.242, P=0.000) and dendritic cells (cor = 0.302, P=0.000) (Figure 6A). This evidence concerns the gene CD4 and neoplasm.