Multivariate cox regression indicated that CDKN2A expression (HR = 2.165, 95% CI: 1.063–4.276, P=0.018) and tumor stage (HR = 5.873, 95% CI: 2.125–10.549, P<0.001) were independent prognostic factors for OS (Figure 4C). The gene discussed is CDKN2A; the disease is neoplasm.