ALB and amyotrophic lateral sclerosis: Furthermore, ALS patients exhibited increased levels of intrathecal total protein (480 mg/l, IQR 362–628) and increased albumin quotients (6.3, IQR 4.5–8.6) as well as frequency of blood/CSF barrier dysfunction (30.0%) compared with controls (total protein 387 mg/l, IQR 340–448, P = 0.005; albumin quotient 4.9, IQR 4.0–5.6, P = 0.008; blood/CSF barrier dysfunction 0%, P = 0.004).