CCI: Controlled cortical impact; EE: Environmental enrichment; TBI: Traumatic brain injury; TO: Temporal order; OBTT: Operation brain trauma therapy; FPI: Fluid percussion injury; PBBI: Penetrating ballistic-like brain injury; SV: Simvastatin; MWM: Morris water maze; GFAP: Glial fibrillary acidic protein; Simvas: Simvastatin. The gene discussed is GFAP; the disease is brain injury.