Our reported data indicated miR-338-3p was downregulated in ovarian cancer, and involved in the growth and metastasis of ovarian cancer cells might due to the regulation of cell proliferation and EMT induced by MACC1, Met and its downstream Wnt/Catenin beta and MEK/ERK signaling pathways 9, 22. This evidence concerns the gene MAP2K7 and ovarian carcinoma.