Furthermore, ROS also stabilize nuclear factor erythroid 2-related factor 2 (NRF2) via the degradation of Kelch-like ECH-associated protein 1 (KEAP1) to enhance the transactivation of Notch homolog 1, translocation-associated (Drosophila) (NOTHC1), promoting the NOTHC1 intracellular domain translocation to the nucleus and leading to Snail transcription, thereby promoting the EMT of cancer cells and favoring cancer cell invasion and metastasis 72. The gene discussed is NOTCH1; the disease is cancer.