The KEGG pathway enrichment analysis of 736 RhoF-related genes screened by Venn diagram (Figure 7A) showed that the most enriched pathways included ribosome, primary immunodeficiency, NF-kappa B pathway, metabolic pathway, insulin resistance, notch signaling, nonalcoholic fatty liver disease (NAFLD) and P53 signaling pathway (Figure 7B). The gene discussed is RHOF; the disease is inborn error of immunity.