CXCL1 and neoplasm: The result of the pair-t test showed that CXCL1 mRNA expression in COAD tumor tissues was markedly up-regulated than in paracancerous non-tumor colon tissues (Fig. 3a), and the diagnostic ROC curve (Fig. 3b) showed that CXCL1 had a high accurately for COAD diagnosis (P<0.0001, AUC (95% Cl)=0.884(0.808-0.961) ).