At the same time, by comparing the expression of CXCL1 between tumor and paracancerous tissues in COAD patients from TCGA cohort, we also observed that the expression of CXCL1 was dysfunctional between tumor and paracancerous tissues, and CXCL1 was significantly up-regulated in tumor tissues. The gene discussed is CXCL1; the disease is colon adenocarcinoma.