Activation of SLC4A4 via inhibited the phosphorylated of P38 to limit the cell death in ischemia-reperfusion injury rat hearts 29; however, inhibition of JNK (SP600125, 10 uM) cannot effect SLC4A4 protein abundance in cortical astrocytes cells 30. The gene discussed is SLC4A4; the disease is ischemia reperfusion injury.