And HE4 not only regulated the expression of Fasl, cyclin D1, caspase 3 and Ki67 to influence tumor apoptosis and proliferation, but also altered metastasis gene expression such as intercellular adhesion molecule 1 (ICAM-1), CD44, matrix metalloproteinase-2 (MMP2) and matrix metalloproteinase-9 (MMP9) to influence tumor metastasis 22, 24, 33. This evidence concerns the gene CCND1 and neoplasm.