As a calcium-dependent phospholipid binding protein annexin ANXA2 II may help HE4 translocate into the nucleus, where it functioned as a transcription factor and increased the expression of MAPK or FOCAL signaling molecules, MAPK interacting serine/threonine kinase 2 (MKNK2) and laminin subunit beta 2 (LAMB2), to promote ovarian cancer cell invasion and metastasis 18. This evidence concerns the gene WFDC2 and ovarian cancer.