Therefore, to investigate the biological roles of SVCT2 in the initiation and progression of CRC, we first examined its expression in human CRC cell lines HCT 116, HCT-15, COLO 320DM, HT-29, DLD-1, Caco2, SW480, SW480E, SW620 and RKO (Fig. 1C). This evidence concerns the gene SLC23A2 and colorectal carcinoma.