Hsa-miR-210 expression is known to be up-regulated by the activation of the HIF1α mediated hypoxia signaling pathway that is a hallmark of ccRCC and was undetectable in the normal parenchyma, but expressed to varying degrees in all morphologic regions of all the tumors (Figure 2) 19. The gene discussed is HIF1A; the disease is nonpapillary renal cell carcinoma.