TARDBP and amyotrophic lateral sclerosis: However, we know that TDP-43 pathology defines subtypes of FTD and ALS-FTD patients, in contrast to ALS patients, show significantly elevated BMI35, 36 and a recent TDP-43Q331K non-overexpressing model also showed weight gain, which was hypothesised as an FTD-related feature as suggested by other FTD-like phenotypes in this model17.