TARDBP and amyotrophic lateral sclerosis type 8: Multiple TDP-43 mouse models have been generated to examine the role of TDP-43 in ALS8 Several overexpression models of wild-type or mutant TDP-43 have been investigated, resulting in a range of phenotypes including bodyweight changes, cytoplasmic TDP-43 inclusions, tremor, muscle atrophy, spasticity, impaired learning, impaired memory and premature death9–14.