We found a lower transcriptional profile, with enrichment for “protein processing in endoplasmic reticulum” and “B receptor signaling pathway” but a relative higher transcriptional profile, with enrichment for “osteoclast differentiation” of IGHG4+ Plasma B in ACPA- RA patients compared with ACPA+ RA patients (Fig. 3c). The gene discussed is IGHG4; the disease is rheumatoid arthritis.