In ACPA- RA, we observed several specific abnormalities in the synovial membrane (Supplementary Table 3), including significant upregulation of CCL13, CCL18 expression in B, DC, and macrophage subsets, and upregulation of MMP3 expression in DC, macrophage, and T cells subsets, respectively. The gene discussed is CCL18; the disease is rheumatoid arthritis.