CTSH and neoplasm: In addition, we observed a significant expansion of C1q+ Macrophages in the Tumor/Healthy Border of Tumor 2 (Benjamini–Hochberg-adjusted p value < 0.001 by Fisher’s exact test)—this cell type was defined by elevated expression of complement components (C1qa, C1qb, and C1qc), cathepsins (Ctsh, Ctsc, and Ctss), and Cx3cr1, which is involved with macrophage migration to inflamed sites.