In sum, the present study not only revealed that c-Myc transactivated KCNQ1OT1 in APL and upregulated KCNQ1OT1 promoted APL cell proliferation, but also demonstrated that KCNQ1OT1 bound to FUS, thus stabilizing the mRNA of MAP3K1 (Fig. 7). The gene discussed is MYC; the disease is acute promyelocytic leukemia.