MAP3K1 and acute promyelocytic leukemia: In sum, the present study not only revealed that c-Myc transactivated KCNQ1OT1 in APL and upregulated KCNQ1OT1 promoted APL cell proliferation, but also demonstrated that KCNQ1OT1 bound to FUS, thus stabilizing the mRNA of MAP3K1 (Fig. 7).