To interrogate the mechanism of KCNQ1OT1 upregulation in APL, we utilized the DNase I HS-sequencing and chromatin immunoprecipitation-sequencing (ChIP-seq) data of NB4 cells generated by the ENCODE Project Consortium [32] to identify the regulatory region of KCNQ1OT1. Here, KCNQ1OT1 is linked to acute promyelocytic leukemia.