CD40LG and COVID-19: The nsp5 protein is also known as the 3C-like protease (3CLpro), which mediates the cleavage and subsequent activation of polyproteins involved in viral replication.38 As such, it has become a target-of-interest for COVID-19 therapy.39 We identified three IgM epitopes (nsp5_3-7, nsp5_103-107, nsp5_123-127) and one IgG epitope (nsp5_93-97) to nsp5 (Fig. 4d, Supplementary Tables 4 and 5).