Although the gene that codes for α-syn (SNCA) is absent in Drosophila, Drosophila models expressing either WT or PD-linked mutant forms of human α-syn replicate several features of PD including loss of dopaminergic neurons, Lewy body-like inclusions and locomotor dysfunction [14, 15], and have been used to isolate the mechanistic roles of α-syn function [14, 16–20]. Here, SNCA is linked to Parkinson disease.