They also reported the expression changes in several transcripts [clusterin (CLU), endothelin 3 (EDN3), low-density lipoprotein receptor-related protein 4 (LRP4), Wnt inhibitory factor 1 (WIF1), adenomatosis polyposis coli downregulated 1 (APCDD1), lymphoid enhancer-binding factor 1 (LEF1), chemokine (C-X-C motif) receptor 4 (CXCR4), matrix gla protein (MGP), and gremlin 1 (GREM1)], including several transcripts known to play an important role in HF generation. The gene discussed is EDN3; the disease is hydrops fetalis.