WWP1 and hepatocellular carcinoma: It should be noted that a previous study reported an oncogenic role for WWP1 in targeting LATS for proteolytic degradation (Yeung et al, 2013), and high expression levels of WWP1 have been implicated in worse prognostic outcomes in hepatocellular carcinoma (Zhang et al, 2015) and prostate cancer (Chen et al, 2007).