Neo-antigens could be recognized as non-self-epitopes and thereby enhance the immune reactivity against tumor cells [34].FCGBP (Fc fragment of IgG binding protein), a key regulator of TGF-1-induced epithelial-mesenchymal transition (EMT), was reported to be associated with the progression and prognosis of gallbladder cancer [35]. Here, FCGBP is linked to gallbladder cancer.