The graph of IRS in Fig. 6B indicates moderate and mild E2 staining in 33 and 12 samples, respectively, and moderate and mild COX-2 staining in 16 and 30 samples, respectively, of the 45 tumor tissues showing a significant difference in proportion between moderate and mild IRS between E2 ( mainly moderate) and COX-2 ( mainly mild). The gene discussed is PTGS2; the disease is neoplasm.