PGE2 is able to promote cancer cell growth through EP2 signaling that involves the activation of survival pathways, such as phosphoinositide 3-kinase (PI3K) and the protein kinase Akt and Extracellular Signal–Regulated Kinase 2 (ERK1/2), that have been implicated in asbestos-mediated mesothelial cell transformation [25–28]. Here, AKT1 is linked to cancer.