ORC1 and Fanconi anemia: We found that MCMs and their related genes were significantly enriched in some important pathways, such as the DNA replication (RFC5, MCM7, RFC2, PRIM1, RPA1, MCM3, MCM4, MCM5, MCM6, and MCM2), cell cycle (RBL1, CDC45, MCM7, ORC1, MCM3, MCM4, MCM5, MCM6, and MCM2), mismatch repair (RFC5, MSH6, MSH2, RFC2, and RPA1), spliceosome (HNRNPM, U2AF2, SRSF1, HNRNPU, SRSF3, and RBMX) and Fanconi anemia (BRIP1, RPA1, USP1, and FANCC) pathways.