For ATB vs non-TB, MMP8 had 0.741 (95% CI, 0.647–0.835) AUC, 70.9% (95% CI, 57.9–81.2%) sensitivity and 59.2% (95% CI, 45.2–71.8%) specificity; CXCL1 had 0.921 (95% CI, 0.871–0.970) AUC, 90.9% (95% CI, 80.4–96.1%) sensitivity and 71.4% (95% CI, 57.6–82.2%) specificity; and S100A8 had 0.764 (95% CI, 0.669–0.858) AUC, 74.5% (95% CI, 61.7–84.2%) sensitivity and 71.4% (95% CI, 57.6–82.2%) specificity (S2 Fig). The gene discussed is MMP8; the disease is tuberculosis.