Abnormal production of some cytokines such as tumour necrosis factor (TNF)-α, interleukin-1-beta (IL- 1β), soluble IL-2 receptor (sIL-2R), IL-6, and chemokine IL-8 have been implicated in the pathogenesis of various inflammatory and autoimmune diseases [43]. This evidence concerns the gene IL6 and autoimmune disease.