We confirmed this finding at the protein level: Neutrophils from patients with COVID-19 were enriched for IFN stimulated gene (ISG) products, with both intermediate and severe cases, compared with control patients without COVID-19, exhibiting elevated levels of canonical ISG products, such as IFN-induced protein with tetratricopeptide repeats 1 (IFIT1), IFN-induced GTP-binding protein MX1 and IFN-induced transmembrane protein 3 (IFITM3, Figure 1D) (22), and, consequently, a marked increase in computed ISG scores (Figure 1E). The gene discussed is IFITM3; the disease is COVID-19.