In a murine model of Angiotensin-II–induced dissecting aortic aneurysms, VSMCs clonally expand and undergo a phenotypic switch toward phagocytic-like cells, which is characterized by the upregulation of phagocytic markers as well as autophagic and endoplasmic reticulum stress markers (38). The gene discussed is AGT; the disease is aortic aneurysm.