IL1B and vasculitis: Since monocytes and macrophages are the main IL-1β producers in cardiovascular lesions during LCWE-induced KD vasculitis (11, 29), we interrogated the role of autophagy in myeloid cells using LysMCreAtg16l1Δ/Δ mice, which harbor a specific deletion of Atg16l1 in myeloid cells (ref. 34 and Figure 3A).