CASP1 and vasculitis: To determine if the beneficial effect of MN58b treatment on LCWE-induced KD vasculitis was mediated by decreased NLRP3 inflammasome activity, we performed FLICA staining on heart tissues and observed that Caspase-1 activity was significantly reduced in LCWE-injected mice treated with MN58b compared with LCWE-injected mice (Figure 6, E and F).