MDSCs are recruited to tumor sites through GM-CSF; monocyte chemoattractant protein 1 (MCP1); CXCL1, 2, 5, and 12; IL-8; CSF1; prokineticin 2 (Prok2); CCL2; S100A8/9; and other factors derived from the TME47,61,62. The gene discussed is CSF2; the disease is neoplasm.