Since expression of neurexin-1 was found to be associated with outcomes in ES, we went on to investigate the expression of neurexin-1 binding partners that regulate its subcellular localisation and synaptic activity in tumour cohort 1, i.e., Amyloid Beta Precursor Protein Binding Family A Member 1 (APBA1), Neuroligin 4 X-linked (NLGN4X) and Neurexophilin 3 (NXPH3). The gene discussed is APBA1; the disease is Ewing sarcoma.